Shin J, et al. - In this retrospective study, the predictive value of DNA repair protein expression for prognosis and responses to platinum-containing chemotherapy was assessed in patients with non-small cell lung cancer (NSCLC) who were treated with preoperative platinum-based chemotherapy, followed by curative lung resection. Using immunostaining, ATM, RAD51, LKB1, H2AX, and SIRT1 expression levels were analyzed in resected tumor specimens. These were used to classify patients and compare survival and responses to chemotherapy. Relative to patients with SIRT1-negative cancer, superior responses to chemotherapy and longer survival durations were observed in those with SIRT1-expressing NSCLC.