Akodad M, et al. - Calcium score (CS) is a well-known prognostic factor after transcatheter aortic valve implantation (TAVI) performed with first-generation prosthesis. Herein, whether CS remains a prognostic factor after Sapien 3 and Evolut R valves implantation, was assessed. CS appeared as an important prognostic factor of major events after TAVI with first-generation valves but not with new generation devices. Furthermore, CS remained associated with AR only with new generation self-expandable Evolut R devices.