Kakkar A, Thakur R, Roy D, et al. - Researchers conducted the study for analyzing the effect of Brandwein-Gensler Histological Risk Score (BG-score) and tumor-infiltrating lymphocyte (TIL) subsets on patient outcomes in oral squamous cell carcinoma (OSCC). For 178 OSCC excisions, the BG-score was calculated, and cases were classified as low-, intermediate-, and high-risk groups. TIL subset immunohistochemistry was performed in 50 cases. According to the results, 25 low-risk (14%), 93 intermediate-risk (52%), and 60 high-risk (34%) cases have been identified. BG-score is a straightforward risk assessment technique with a high prognostic impact. Tumor host immune response has a major impact on prognosis, with increased CD8+ and low FOXP3+ cells being linked to improved outcomes. The case is made for BG-score and TIL subset identification to be included in the routine histopathologic evaluation of OSCC as biomarkers for risk stratification and adjuvant treatment planning.