Cardoso CRL, et al. - In a prospective cohort of patients with resistant hypertension, researchers assessed the occurrence of adverse cardiovascular outcomes and mortality in relation to aortic stiffness via carotid-femoral pulse wave velocity (cf-PWV). Participants included 891 resistant hypertensive patients who were follow-up for a median of 7.8 years. The investigators assessed aortic stiffness at baseline, and used multivariate Cox analysis to examine the links between cf-PWV and the occurrence of total cardiovascular events (CVE), major adverse CVEs, and cardiovascular and all-cause mortalities. A CVE (123 major adverse CVEs) occurred in 138 patients, and death was reported for 142 patients during follow-up. In resistant hypertensive patients, adverse cardiovascular outcomes and mortality were predicted by increased aortic stiffness. Furthermore, aortic stiffness offered significant improvement for cardiovascular risk stratification in these patients. Thus, the authors recommended inclusion of cf-PWV measurement into the routine clinical management of patients with resistant hypertension.