Yu T, Jiao Y, Song J, et al. - Via a prospective cohort study of a total of 6,368 individuals with the acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) from January 1, 2010, to December 31, 2017, researchers determined the prognostic influence of alkaline phosphatase for in-hospital mortality in individuals with ACS. Both as a constant variable and according to three sections, ALP was analyzed. In-hospital mortality was significantly greater in Tertile 3 group when compared with the other two groups, following multivariable adjustment. The ALP level was related to an elevated risk of in-hospital mortality, when ALP was assessed as a constant variable, following the multivariable adjustment. For prognosticating in-hospital mortality, the c-statistic of ALP was 0.630. The cut-off value was 72 U/L with a sensitivity and a specificity of 0.764 and 0.468, respectively. Nevertheless, the prognostic performance of the Global Registry of Acute Coronary Events (GRACE) score could not significantly be enhanced by ALP. Hence, ALP was an independent predictor of in-hospital mortality in individuals with ACS who were undergoing PCI. However, it could not improve the prognostic performance of the GRACE score.