Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients
BMC Cancer Aug 26, 2017
Lee YS, et al. Â A research was undertaken to probe the clinical impact of NLR as a prognostic factor in malignant pleural effusion (MPE) (mNLR) and a new scoring system that use NLRs in the serum and MPE (smNLR score) in lung cancer patients. For this group of patients, the new smNLR score was determined as a useful and costÂeffective prognostic factor.
Methods
- All of the patients who were diagnosed with lung cancer and who presented with pleural effusion, were retrospectively reviewed.
- Analysts only included patients with malignant cells in the pleural fluid or tissue to maintain the quality of the study.
- Three smNLR score groups were formed for the patients.
- They examined clinical variables for their correlation with survival.
Results
- They classified 158 patients into three smNLR score groups as follows: 84 (53.2%) had a score of 0, 58 (36.7%) had a score of 1, and 16 (10.1%) had a score of 2.
- High sNLR, mNLR, and increments of the smNLR score were associated with shorter overall survival (p < 0.001, p = 0.004, and p < 0.001, respectively), in a univariate analysis
- Significant prognostic factors were age, Eastern Cooperative Oncology Group performance status (ECOG PS), histology, M stage, hemoglobin level, albumin level, and calcium level, and independent predictors of overall survival were ECOG PS (p < 0.001), histology (p = 0.001), and smNLR score (p < 0.012).
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries