Fakhreddine MH, et al. - In this population-based study, researchers searched for evidence to support less aggressive treatment in early-stage invasive papillary breast cancer (IPBCA). For this purpose, they analyzed prognostic factors, treatment, and outcomes of IPBCA cases from 1990 to 2009 of the recent Surveillance, Epidemiology, and End Results, including patients with stage T1-2, N0 IPBCA. Treatment modalities included lumpectomy alone (LA), lumpectomy with radiation treatment (LRT), and mastectomy alone (MA). LRT was found to be related to superior overall survival (OS) for early-stage invasive papillary BCA patients, relative to LA or MA. The standard of care breast conservation approach for patients with invasive papillary BCA was supported. The prognostic factors that were found to be related to worse OS were increased age, higher T-stage, higher histologic grade, and black race.