Parkes A, et al. - Researchers determined factors suggestive of high-risk in 1,445 patients with metastatic breast cancer with bone-only metastases (BOM) followed for at least 6 months at MD Anderson Cancer Center from January 1, 1997 to December 31, 2015. At time of BOM diagnosis, 71% (n=936) of the 1,325 patients with BOM with available pain characterization were symptomatic. Several risk features for decreased OS in this unique patient population were successfully identified in this study. These risk features included multiple bone metastases and both axial and appendicular skeleton involvement. According to findings, increased pain was reported in relation to multiple bone metastases and lytic bone metastases.