Kamiya Y, Fujisawa T, Kono M, et al. - Researchers undertook this retrospective analysis to assess predictive factors related to a worse prognosis in 99 consecutive patients with primary Sjögren syndrome (pSS)-interstitial lung disease (ILD). At the time of diagnosis, the evaluation of clinical features, laboratory findings, and pulmonary function tests was done. Two experienced chest radiologists reviewed chest HRCT images. The study sample had a median age of 68 years (73% women). A significant link between prognosis and age, serum Krebs von den Lungen-6 (KL-6) levels, and %FVC was shown in univariate analysis. A significant link of KL-6 > 800 U/mL with worse prognosis was revealed using optimal cutoff levels, according to receiver operating characteristic curve analyses. A higher mortality rate was observed in patients with high serum KL-6 levels (> 800 U/mL) vs those without high serum KL-6 levels. Findings revealed lower %FVC and higher serum KL-6 levels as predictors of poor outcome in patients with pSS-ILD.