Abu-Arja MH, Osorio DS, Lassaletta A, et al. - The following factors were not associated with improved outcomes in patients with relapsed central nervous system nongerminomatous germ cell tumors: local relapse site, gross total surgical resection, and radiotherapy at relapse.

• This analysis involved 9 studies with 101 patients; 33 (33%) were alive 12 months post-initial relapse.

• Survivors comprised 60% of patients with serum/cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) level ≤25 ng/mL at initial diagnosis vs 28% among patients with serum/CSF AFP level >25 ng/mL.

• Complete response/continued complete response (CR/CCR) by the end of therapy at relapse was obtained in 71% of patients, and these were survivors vs 7% among patients who had less than CR/CCR.

• 48% of patients who underwent marrow-ablative chemotherapy followed by autologous hematopoietic cell rescue (HDCx/AuHCR) post-relapse were survivors relative to 12% among patients who did not undergo HDCx/AuHCR.