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Prognostic factors for event-free survival in liver transplantation for hepatoblastoma: A single-center experience

Pediatric Transplantation Sep 25, 2019

Lauferman L, Halac E, Aredes D, et al. - In this retrospective cohort study, researchers assessed the success of liver transplant (LT) in achieving complete and permanent remission of unresectable hepatoblastoma (HB), the most common malignant liver tumor in children. They retrospectively analyzed 21 patients with HB who had LT between January 1, 2005, and May 1, 2018, to analyze the risk factors to event-free survival (EFS) that influence the clinical result of patients with HB receiving LT. Data reported that overall survival was 90%. According to multivariate analysis, patients with higher values of pretransplant AFP (> 16,000 ng/dL) had a significantly higher risk of EFS than those transplanted with lower levels. Efforts should be produced to enhance the selection of LT candidates for unresectable HB, with a view to improving the definition of chemoresistance as a risk factor for poor results.
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