vor der Holte AP, et al. - In this retrospective study, researchers identified and evaluated potential clinical and molecularbiological risk factors for development and recurrence of sinonasal papillomas (ie, inverted (IP), fungiform (FP), and oncocytic papillomas (OCP)). The risk factors examined included age, gender, tumor size and localization, tobacco smoking, daily consumption of alcohol, essential hypertension, anticoagulant medication, allergies, surgical approach, and HPV infection. HPV 6, 11, and 16 were the most commonly detected HPV types. However, patients also showed HPV types that have rarely or not at all been described in sinonasal papillomas before, such as HPV 58, 42, 83, and 91. Risk factors for recurrence of sinonasal papillomas were young age at initial diagnosis and incomplete tumor resection. The data suggest the development and/or perpetuation of sinonasal papillomas is supported by HPV infection. Furthermore, sinonasal papillomas tend to exhibit an unique subset of genotypes of HPV, including genotypes not often described earlier.