vor der Holte AP, et al. - Using regression analysis, researchers identified and evaluated potential clinical and molecularbiological risk factors for development and recurrence of sinonasal papillomas [ie, inverted (IP), fungiform (FP), and oncocytic papillomas]. The risk factors examined included age, gender, tumor size and localization, tobacco smoking, regular consumption of alcohol, essential hypertension, anticoagulant medication, allergies, surgical approach, and HPV infection. According to this retrospective study, the recurrence of Schneiderian papillomas is independent of conventional risk factors apart from age and incomplete tumor resection. In this investigation, patients showed higher rates of HPV infection in IP and FP compared with healthy mucosa, which is reported 0–5.8% in Germany and central Europe. The risk factors for the recurrence of sinonasal papillomas are young age at initial diagnosis and incomplete tumor resection. The data suggest that development and/or perpetuation of sinonasal papillomas is supported by HPV infection. In addition, sinonasal papillomas tend to exhibit a particular group of genotypes of HPV, including genotypes not frequently described earlier.