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Prognostic effect of incongruous lymph node status in early-stage non-small cell lung cancer

European Journal of Surgical Oncology Sep 16, 2020

Chen JX, Lu TY, Lin YS, et al. - Among patients with a completely resected pN0 non-small cell lung cancer (NSCLC) less than 4 cm, this inquiry was performed to determine how tumor recurrence can be impacted by positron emission tomography/computed tomography (PET/CT) in this patient population. This study involved 211 consecutive patients. They reported the maximum of standard uptake value (SUVmax) of primary tumor and the presence of positive lymph nodes on PET/CT scans. A reduced 5-year disease-free survival was observed in patients with positive lymph nodes on PET/CT. In multivariable analysis, significant factors for tumor recurrence were tumor SUVmax >2.93, the presence of positive lymph nodes on PET/CT, and poor differentiation. Overall, in this patient population, a high risk of recurrence can be predicted by the presence of positive lymph nodes on PET/CT scans. This finding assists in the recognition of patients for whom adjuvant therapy may be beneficial.

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