Zhang XM, et al. - In patients with head and neck squamous cell carcinoma (HNSCC), researchers ascertained if the in-situ tumor-infiltrating immune lymphocytes, as a novel companion to the Immunoscore analysis, could be a promising, valuable prognostic and predictive marker. Using immunohistochemistry in tumor nests and stroma gotten from patient surgical specimens, total (CD3+) and cytotoxic (CD8+) T lymphocytes were evaluated. It was observed that the Immunoscore system was able to forecast the prognosis of HNSCC. Therefore, it could be a useful prognostic marker. Results of this study suggested that the measurement of CD3+ and CD8+ cell infiltration could be useful in HNSCC subjects. In addition, it might help determine which patients may benefit most from definitive chemoradiotherapy.