Ravanelli M, Agazzi GM, Milanese G, et al. - Researchers assessed the prognostic and predictive value of computed-tomography histogram analysis (CTHA) in platinum-refractory non-small cell lung carcinoma (NSCLC) managed with nivolumab, an immune checkpoint inhibitor. Participants (n = 104) were recruited from 3 different centers. Using the proprietary software TexRAD, CTHA was performed, and histogram features were obtained at different spatial scale (spatial scale filters, SSF). Overall 30 CTHA features per patients were produced. With a hazard ratio (HR) of 0.476 (95%CI 0.29-0.77), kurtosis obtained by SSF  =  4 mm was selected by least absolute shrinkage and selection operator as the single feature associated with overall survival, and a link of kurtosis SSF  =  6 mm with progression-free survival, with HR of 0.556 (95%CI 0.36-0.86), was also found. A possible role of CTHA in stratifying prognosis and treatment response in patients with NSCLC treated with nivolumab was suggested for the first time in this study.