Ueno M, Kawai M, Park JY, et al. - Given the prognostic influence of epithelial-mesenchymal transition genes on hepatocellular carcinoma (HCC) and the previous consideration of the following four epithelial-mesenchymal transition–related genes as significantly influential: E-cadherin (CDH1), inhibitor of DNA binding 2 (ID2), matrix metalloproteinase 9 (MMP9), and transcription factor 3 (TCF3), development of a prognostic prediction model, NRISK4 = (−0.333 × [CDH1] − 0.400 × [ID2] + 0.339 × [MMP9] + 0.387 × [TCF3]) was done, but from patients with HCC with predominantly hepatitis B virus infection. Researchers conducted this work to determine the validity of this model for patients with HCC and hepatitis C virus (HCV) infection. HCC tissue samples from 67 patients with HCV infection were obtained. This cohort had an area under the curve of NRISK4 prediction of 0.70 and an appropriate cutoff value of 3.19. Using this cutoff value, they divided patients into high- (n = 25) and low-risk (n = 42) patients for prognosis. The analysis revealed the possible utility of NRISK4 model in successfully validating the prognosis of patients with HCC with HCV infection similar to that reported previously in patients with hepatitis B virus infection, particularly in the early period after surgery.