Kim TH, Seo YS, Kang SH, et al. - In patients with decompensated cirrhosis, researchers assessed the best serum and urine markers to assess their prognosis in this prospective observational analysis. Hospitalized cases of decompensated cirrhosis were examined by obtaining measurements of serum creatinine and cystatin C (CysC), and urinary N‐acetyl‐beta‐D glucosaminidase (uNAG) and neutrophil gelatinase‐associated lipocalin levels. Independent predictors of acute kidney injury (AKI), as found in multivariate analysis, were serum CysC and uNAG levels, with optimal cut‐off values of 1.055 mg/L and 23.1 U/g urinary Cr, respectively. On grouping patients into three categories, using these cut‐off values (group 1, both low; group 2, one of two high; and group 3, both high), experts found significant differences in progression of AKI during hospitalization, incidence of AKI in patients without AKI at baseline and death rate, according to serum CysC and uNAG concentrations. Overall, experts concluded the usefulness of serum CysC and uNAG levels as prognostic markers for renal outcomes and mortality in patients suffering from decompensated cirrhosis.