Matsuo K, et al. - In this study, the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer was examined. Observation revealed that stage I endometrioid Synchronous endometrial and ovarian cancer (SEOC) and stage I non-SEOC had similar survival outcomes.

Methods

• From 1973 to 2013, researchers performed a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program.
• After propensity score matching, they compared survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692).

Results

• Compared to women without synchronous ovarian cancer, women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy (all, P < 0.001).
• The presence of synchronous ovarian cancer in a propensity score matched model seemed not associated with endometrial cancer-specific survival (10-year rates 96.0% vs 95.3%, P=0.97) or overall survival (85.6% vs 87.2%, P=0.10).
• Survival was similar among tumors with concordant grades at the two cancer sites regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% vs 89.1%, P=0.40; and grade 2 tumors, 84.0% vs 85.8%, P=0.78).