Matsuo K et al. -Synchronous endometrial and ovarian cancer with endometrioid histology has a good prognosis. In the current study survival in early-stage endometrioid endometrial cancer with synchronous early-stage endometrioid ovarian cancer was determined.It was shown that stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to stage I endometrioid endometrial cancer without synchronous ovarian cancer.

Methods

• This was a retrospective case-control study.
• Survival in patients with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) was compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692).

Results

• Patients with synchronous stage I endometrioid ovarian cancer had the following characteristics: recent diagnosis; younger; stage IA disease; grade 1 tumor; s/p lymphadenectomy; and less likely to receive radiotherapy compared to patients without synchronous ovarian cancer.
• The presence of synchronous ovarian cancer was not associated with endometrial cancer-specific survival (10-year rates 96.0% vs. 95.3%) or overall survival (85.6% vs. 87.2%).
• Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% vs. 89.1%; and grade 2 tumors, 84.0% vs. 85.8%).