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Prognosis for intracerebral hemorrhage during ongoing oral anticoagulant treatment

Acta Neurologica Scandinavica Feb 20, 2019

Apostolaki-Hansson T, et al. - Using data from the Swedish Stroke Register (Riksstroke) and the Swedish Causes of Death Register between 2012 and 2016, investigators compared 90-day survival and functional outcome following non-Vitamin K Antagonist oral anticoagulants (NOAC)-intracerebral hemorrhage (ICH), the most serious adverse effect of treatment with oral anticoagulants, with vitamin-K antagonists (VKA)-ICH. On the basis of the modified Rankin Scale (mRS), the estimated functional results at 90 days were compared with the ICH associated with VKA and NOAC using a chi-squared test. Participants in the study were 2483 patients (300 with NOAC-ICH and 2183 with VKA-ICH). Increased age and reduced level of consciousness were factors predicting death. No significant difference in mortality and functional outcome at 90 days was observed between NOAC-ICH vs VKA-ICH in this large study on anticoagulant-associated ICH.
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