Cameli M, et al. - Researchers developed a novel prognostic echocardiographic score in this study involving 110 patients with advanced chronic heart failure (CHF). Using standard, 3D, and speckle tracking echocardiography, they analyzed participants, who were followed prospectively for 2±0.7 years. Major adverse cardiac events (MACE) were recorded during this time period. They computed a prognostic score formula as: PROBE Score=1(if left atrial volume index > 65mL/m²)+1(if right ventricular sphericity index > 0.53)+0.5(if right ventricular fractional area change < 36.5%)+1(if free wall right ventricular longitudinal strain > -14%). Via receiver operating characteristic analysis, they generated an area under the curve of 0.90. Participants were characterized as being at low (PROBE ≤ 1), intermediate (PROBE=1-2), or high (PROBE > 2) risk for MACE. Overall, good predictive value for MACE was displayed by the PROBE score (with first and second level echocardiographic parameters). In patients with advanced CHF, its use may enables a non-invasive, individualized, and accurate evaluation and stratification of prognosis.