Arcos-Montoya D, Wegman-Ostrosky T, Mejía-Pérez S, et al. - Whether progesterone receptor (PR) phosphorylation together with protein kinase C alpha (PKCα) expression could serve as a prognostic factor for astrocytomas malignancy, was inquired in this study. Researchers analyzed 46 biopsies from Mexican patients with different astrocytoma malignancy grades, to determine the content of PKCα, PR and its phosphorylation at Ser400, using immunofluorescence. They found the presence of a positive correlation between the tumor grade and the content of PKCα, PR and its phosphorylation at Ser400, as well as the intracellular colocalization of these proteins. PR and PKCα expression at mRNA level was shown to have an inverse ratio with astrocytomas tumor grade, as revealed by employing an in silico assay. In the light of these observations, it could be considered that PR and its phosphorylation at Ser400 site, as well as PKCα and their colocalization represent possible malignancy biomarkers for astrocytomas grades I–IV.