Wood S, et al. – A randomised clinical trial and updated meta–analysis are done to report the results of their trial of treatment with 200 mg vaginal progesterone in women with arrested premature labor along with a meta–analysis of all types of progesterone for maintenance tocolysis. The outcome of this trial is suggested that the progesterone is not effective for preventing preterm birth following arrested preterm labor.

Methods

• A randomized double blinded clinical trial is designed in this study.
• In this research, they studied the daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an updated meta–analysis.

Results

• They noticed clinical trial was terminated early after 41 women were enlisted.
• Vaginal progesterone treatment did not change the median gestational age at delivery: 36+2 weeks versus 36+4 weeks, p = .865 nor increase the mean latency to delivery: 44.5 days versus 46.6 days, p = .841.
• In the updated meta–analysis, progesterone treatment reduced delivery <37 weeks gestation and increase latency to delivery, but this treatment impact was not clear in the high quality trials: (OR 1.23, 95% CI 0.91, 1.67) and (–0.95 days, 95% CI –5.54, 3.64) respectively.