Algra AM, et al. - Researchers performed this systematic review and meta-analysis of 114 studies with 106,433 patients to investigate the 30-day clinical complication risk and case-fatality rate of endovascular treatment (EVT) and neurosurgical treatment (NST) of unruptured intracranial aneurysms. Analysis of 74 studies on endovascular treatment revealed procedural clinical complication risk of 4.96%, and the case-fatality rate of 0.30%. Female sex, diabetes, hyperlipidemia, cardiac comorbidity, wide aneurysm neck (>4 mm or dome-to-neck ratio >1.5), posterior circulation aneurysm, stent-assisted coiling, and stenting are the factors associated with complications from EVT. Analysis of 54 studies on NST revealed the pooled complication risk of 8.34% and the case-fatality rate of 0.10%. Factors associated with complications from NST included age, female sex, coagulopathy, use of anticoagulation, smoking, hypertension, diabetes, congestive heart failure, posterior aneurysm location, and aneurysm calcification.