Pekkarinen PK, et al. - Given the association of procalcitonin and presepsin with inflammation, researchers investigated whether these biomarkers reflect the severity of post-cardiac arrest syndrome and predict short-term hemodynamical instability and long-term neurological outcome after cardiac arrest. In this subcohort analysis of a prospective, observational, multicenter study, they obtained plasma from 277 patients in the intensive care unit who were treated following out-of-hospital cardiac arrest (OHCA). Findings revealed hemodynamical instability and worsened long-term outcome in correlation with elevated procalcitonin in patients who experienced OHCA. However, the researchers cautioned that, as this association is not very strong, it should not be used as a single predictor. Presepsin was not found to be clinically relevant for risk stratification after OHCA.