Shilpakar R, Paudel BD, Neupane P, et al. - In this prospective, observational study, researchers investigated whether the biomarkers procalcitonin (PCT) and C-reactive protein (CRP) hold clinical significance in patients with febrile neutropenia (FN) receiving chemotherapy for acute leukemia. In 67 patients with acute leukemia, 124 episodes of FN were reported. As a predictor of bacteremia, PCT was found superior to CRP. In the bacteremia group vs in the group without bacteremia, the median PCT level was 3.25 ng/mL vs 0.51 ng/mL, respectively, and the median values of CRP in these groups were 119.3 mg/L and 94.5 mg/L, respectively. Overall, findings revealed the efficacy of PCT as a biomarker to predict bacteremia in patients with FN undergoing chemotherapy for acute leukemia.