Velasco M, et al. - Among 314 hospitalized patients (mean age was 76 years) who started antibiotic treatment, researchers assessed the impact of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD). Study participants were randomized (2:2:1) to get a daily amount of 200 mL of placebo-yogurt (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus), 200 mL of probiotic yogurt (previous plus Lactobacillus acidophilus La-5, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus casei subsp. casei Lc-01 or no yogurt (unblinded control) within 48 hours of starting the antibiotic therapy and up to 5 days after discontinuing the antibiotic. To determine occurrence of diarrhea, participants were followed up with for 1 month. According to this randomized, double-blind, placebo-controlled clinical trial, diarrhea rate was 23.0% in the probiotic group vs 17.6% in the placebo group, absolute risk reduction −5.35%. Among hospitalized patients, the combined probiotic strains LA-5, BB-12, and LC-01 have no effect on the prevention of AAD.