Wang JD, et al. - Clinical data and tissue from 100 nodal mantle cell lymphoma (MCL, an aggressive B-cell lymphoma cases) between 1988 and 2009 were obtained from three large academic medical centers in order to determine whether BIM expression could be related to tumor cell survival. Individuals with high BIM expression were less inclined to have progressive disease and more prone to have a complete response as anticipated for a proapoptotic tumor suppressor. Moreover, a trend was exhibited by high BIM-expressing MCL tumors toward enhanced overall survival with this trend continuing in the sub-analysis of Ann Arbor stages III and IV. Between BIM expression, Ki-67 index, and MIPI score, no relationship was noted, implying a role for BIM as a novel independent prognostic factor. Since BIM is only one member of a complex family of apoptosis-regulating proteins, these verdicts could produce clinically appropriate data for the prognosis and therapeutic susceptibility of MCL.