Veronese N, et al. - This paper ascertained if higher Dietary Inflammatory Index (DII) scores correlated with fractures in North American population. The data shed light on the connection between higher dietary inflammatory index values with a higher risk of incident fractures in women but not in men.

Methods

• This trial constituted a longitudinal study with a follow-up of 8 years. 3648 participants (1577 males and 2071 females; mean age = 60.6 years) with/at risk of knee osteoarthritis participating with in the Osteoarthritis Initiative were recruited as a part of this study.
• DII scores were computed through the validated Block Brief 2000 Food Frequency Questionnaire, categorized into sex-specific quintiles.
• Data on fracture incidents were gained via self-reported history of fractures at hip, spine, and forearm.
• Cox’s regression analysis gauged the link between baseline DII score and incident fracture, adjusted for potential baseline confounders, and reported as hazard ratios (HRs).

Results

• 560 candidates reported fracture (15.4%) incidents, during 8 years of follow-up.
• After adjustment for 10 potential confounders, women in the highest DII score quintile (i.e., most pro-inflammatory diet) exhibited a substantially higher risk for fractures (HR = 1.46; 95% CI = 1.02-2.11)than those in the lowest quintile.
• A rise in one standard deviation of DII scores prominently speculated the fracture onset in women (adjusted HR = 1.14; 95% CI = 1.02-1.27).
• No marked connection was discovered between DII score and fractures, among men or in the sample as a whole.