Wang JD, et al. - Clinical data and tissue from 100 nodal mantle cell lymphoma (MCL), an aggressive B-cell lymphoma, cases between 1988 and 2009 were gathered from three huge academic medical centers by the researchers in order to validate the hypothesis that BIM expression may be correlated with tumor cell survival. Individuals with high BIM expression were less disposed to have progressive disease and more prone to have a complete response as expected for a pro-apoptotic tumor suppressor. Moreover, high BIM-expressing MCL tumors exhibited a trend toward progressed OS with this trend continuing in sub-analysis of Ann Arbor stages III and IV. No relationship between BIM expression, Ki-67 index, and MIPI score was recognized, implying a role for BIM as a novel independent prognostic factor. In conclusion, While BIM is only one member of a complex family of apoptosis-regulating proteins, these conclusions may generate clinically appropriate data for the prognosis and therapeutic susceptibility of MCL.