Kazarian GS, Deirmengian CA, Kazarian ER, et al. - A retrospective review of an institutional database of total knee arthroplastis (TKAs) was performed to evaluate whether and how prior manipulation under anesthesia is a prognosticator of contralateral manipulation in staged bilateral total knee arthroplasty. Following TKA#1, individuals were categorized into two groups: those who had undergone manipulation under anesthesia (MUA) (Group MANIP) and those who did not (Group NO MANIP). The subsequent risk of undergoing MUA following TKA#2 was then evaluated and compared between the two groups. χ 2 tests were applied for comparison. Researchers enrolled a sum of 5,330 patients who had undergone primary uncomplicated staged bilateral TKAs (10,660 knees) during the study period. During the first TKA of a staged bilateral TKA, individuals who undergo MUA are 14.3 times more likely to undergo a subsequent MUA than those who did not undergo MUA following their first TKA.