Gordon A, et al. - Researchers examined the large 2016 Zika epidemic in Managua, Nicaragua, with well-characterized dengue virus (DENV) infection histories to examine the impact of pre-existing DENV immunity on the susceptibility to Zika virus (ZIKV) from January 1, 2016, to February 28, 2017. They identified 560 symptomatic ZIKV infections and 1356 total ZIKV infections (symptomatic and inapparent). They concluded that children with previous DENV infection had lower rates of symptomatic Zika as compared to children who did not have prior DENV infection.