Wu J, Wang YC, Luo WJ, et al. - Researchers investigated how surgery could impact survival of patients diagnosed with primary urethral carcinoma (PUC). They used the SEER database to select 1544 PUC patients diagnosed between 2004 and 2016. They found significantly better 5-yr overall survival (OS) in patients treated with either local therapy (39.8%) or radical surgery (44.7%) vs those receiving no surgery of the primary site (21.5%). In multivariate analyses, primary site surgery was shown to be independently related to better OS and decreased cancer-specific mortality. In non-metastatic PUC patients, a survival benefit was achieved by performing surgery for the primary tumor.