Buller LT, et al. - A total of 10,014 patients were involved in a retrospective analysis in order to ascertain whether high-viscosity cement (HVC) use during primary TKA is independently related to aseptic loosening (AL) needing revision. In the HVC cohort vs the low-viscosity cement cohort, revision for AL was significantly higher. Logistic regression illustrated HVC to be independently correlated with greater odds of revision for AL. Younger age was also correlated with greater odds of revision for AL. BMI, gender, laterality, preoperative diagnosis, and antibiotics in the cement were not related to revision for AL. Implant manufacturer, implant design, and cement brand all affected the odds of undergoing revision for AL. Thus, however, HVC is an engaging option for use in primary TKA, this aptly controlled study showed greater odds of revision for AL when using HVC with various distinctive implant types.