Demarchi J, et al. - The incidence rate of extraglandular manifestations (EGM) in Primary Sjogren's Syndrome (pSS) patients with and without hydroxychloroquine (HCQ) therapy was compared in this study. The outcome of this study revealed that the lower incidence of EGM, seen in patients on HCQ therapy, supports its effectiveness in pSS. However, further large-scale prospective studies are needed to affirm these findings.