Go AS, Tan TC, Chertow GM, et al. - Higher adjusted rates of ESKD, cardiovascular outcomes (acute coronary syndrome, heart failure, ischemic stroke, venous thromboembolism) and death were found in adults suffering from primary nephrotic syndrome, and the risk of ESKD development differed significantly depending on underlying etiology.

• An integrated health care delivery system (Kaiser Permanente Northern California) was used.

• Participants were 907 primary nephrotic syndrome patients with mean age 49 years; 43% were women.

• Controls included a 1:100 time-matched cohort of adults without diabetes, diagnosed nephrotic syndrome, or proteinuria.

• Multivariable Cox regression was applied for comparison between patients and controls.

• For FSGS and membranous nephropathy, a significantly higher excess ESKD risk was observed relative to presumed minimal change disease.