Mulatero P, Burrello J, Williams TA, et al. - This study was sought to assess the clinical spectrum and knowledge of the molecular mechanisms underlying primary aldosteronism (PA), the most frequent form of endocrine hypertension, has evolved over recent years. Researchers conducted a systematic search of PubMed for studies related to the renin-angiotensin-aldosterone system (RAAS), PA, and adrenal histopathology in the elderly population. It was demonstrated that several studies exhibited an age-dependent decrease in the activity of RAAS, together with a progressive decrease of the aldosterone response to sodium intake, especially after the sixth decade of life. The data implied that RAAS physiology and regulation show age-related alterations. Future research is needed to evaluate what extent these variations might influence the diagnostic workup of patients affected by PA.