Hildebrand KA, Schneider PS, Mohtadi NGH, et al. - A randomized clinical trial was designed to explore the use of ketotifen fumarate (KF) to decrease posttraumatic contractures after elbow fractures and/or dislocations. Researchers included a total of 151 individuals sustaining operative or nonoperatively managed isolated distal humerus or proximal radius ± ulna fractures or elbow dislocations within 7 days of injury at three hospitals in Calgary, Canada, including one Level 1 trauma center..The findings suggested that KF did not decrease posttraumatic contractures in a population of operative and nonoperatively managed elbow fractures and/or dislocations. In this population, when compared with placebo, the administration of KF was not found to result in a significantly higher number of major adverse events.