Fitzgerald JP, et al. - Researchers performed a comparison between different strategies used to avoid hypotension in women receiving spinal anaesthesia for caesarean section, via this systematic review and network meta-analysis. From MEDLINE and Embase, Web of Science, they identified relevant randomized controlled trials comparing a preventive intervention with another intervention or inactive control. Overall 109 trials (8,561 women) including 12 different methods were analyzed. The documented most effective to least effective methods, ranked by OR (95%CI), were: metaraminol; norepinephrine; phenylephrine; ephedrine; colloid administered prior to induction of anaesthesia; angiotensin 2; colloid administered following anaesthesia induction; mephentermine; crystalloid delivered following induction of anaesthesia; and crystalloid administered prior to anaesthesia induction. Phenylephrine vs control resulted in maternal bradycardia. A greater lowering in umbilical artery pH was observed with ephedrine vs phenylephrine. Based on the findings, the administration of vasopressors to healthy women is recommended in order to prevent hypotension during caesarean section with spinal anaesthesia.