Kanterewicz E, et al. - A longitudinal analysis of 2,510 women aged 59–70 years engaging in the FRODOS prevalence study (2006–2009) with assessable vertebral fracture assessment (VFA) following 4 years was done in order to examine the incidence of VF, the correlated risk factors, and especially the role of minor vertebral deformities (MVD) in this cohort of cases. In all, the incidence of VF was 6.6%, rising with prevailing VF and in women with widespread MVD. Age and low BMD were also correlated risk factors as were the presence of rheumatoid arthritis and exposure to glucocorticoids and bisphosphonates. Hence, the presence of prevalent VF evaluated by VFA is related to additional incident spinal fractures in postmenopausal women. Moreover, having MVD bestows a progressed risk of new VF.