Lwanira CN, et al. – This study was planned to assess the prevalence of selected host genetic markers and their relationship to malaria incidence in the vaccine trial site of Iganga, Uganda. Researchers realized an association of mutation (NOS2 -954 G>C; rs 1800482) of nitric oxide synthase 2 gene promoter with a lower incidence of acute malaria. The normal haemoglobin (wild genotype; HbAA) seemed associated with reduced malaria incidence rates during the first year of life. More study was recommended to assess the interplay between host genetics and malaria susceptibility.