Schissler AJ, et al. - In a real-life clinical setting at a large academic medical center, the frequency of paradoxical bronchoconstriction was evaluated. Data from 4593 subjects who underwent pre- and post-bronchodilator spirometry testing were analyzed. Before and after the administration of an inhaled short-acting β₂-agonist, the researchers evaluated the forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC). The data presented in this work showed a significant subset of patients experienced paradoxical bronchoconstriction after albuterol administration. No significant associations were found between paradoxical bronchoconstriction and sex, race/ethnicity or body mass index.