Putri RR, et al. - In this nationwide cross-sectional cohort study, researchers sought to examine the prevalence of varying degrees of increased alanine aminotransferase (ALT) in a large cohort of children and adolescents with obesity and to evaluate the correlations of increased ALT with gender, age, degree of obesity, and metabolic risk parameters. Individuals between the ages of 5 and 17.99 who were enrolled in the Swedish Childhood Obesity Treatment Register (BORIS) before March 2020 were eligible. Participants in the study were 11,776 people (age 11.0 ± 3.3 years, 53.5% males). Data reported that the prevalence of mildly and markedly increased ALT were 37.9 and 10.6%, respectively. In boys, the risk of significantly increased ALT increased exponentially with age, but not in girls. Individuals with mildly and significantly increased ALT were found to be more obese. Furthermore, metabolic abnormalities were more common in people with mildly and significantly increased ALT.