Sricharoenchai S, Kerr SJ, Gatechompol S, et al. - Researchers examined vaccine-naïve, sexually active Asian female adolescents with and without perinatally acquired HIV infection (PHIV) for the prevalence of 7 high-risk human papillomavirus (HPV) types in the nonavalent vaccine (HRVT-7: HPV 16, 18, 31, 33, 45, 52, 58). They conducted a 3-year observational cohort study including 93 PHIV female adolescents (median CD4 593 cells/mm³, 62% with HIV RNA suppression; 12–24 years of age) and 99 HIV-uninfected controls (median lifetime sex partners two) matched by age and number of lifetime sex partners in Thailand and Vietnam. HRVT-7 infection was already present in half of sexually active Asian female adolescents, regardless of HIV infection, emphasizing the necessity for earlier access to HPV vaccine in the region. Overall, the risk of HRVT-7 infection and/or positive HPV 16/18 antibodies was higher in correlation with reporting more lifetime partners [≥ 3 vs 1] and having other sexually transmitted infections; while detectable HIV RNA were correlated with increased risk in PHIV adolescents.