Domgue JF, et al. - In this cross-sectional study, researchers examined 75 women with high-grade dysplasia or carcinoma of the cervix, vagina or vulva in order to estimate the prevalence of high-grade anal dysplasia in these subjects. Anal cytology, anal HPV testing with Cervista HPV16/18 and high-resolution anoscopy were performed. Six patients (8.0%) received the diagnosis of anal HSIL (high-grade squamous cell intraepithelial lesion) based on composite endpoints of the most severe cytology or histology result. In 2 (2.7%), 12 (16.0%), 2 (2.7%), and 59 (78.7%) patients, they detected HSIL, atypical squamous cells of undetermined significance, low-grade squamous cell intraepithelial lesion, and normal findings, respectively, on anal cytology. Findings revealed an elevated prevalence of anal HSIL among women with HPV-related lower genital tract dysplasia or cancer.