Kraya T, et al. - Researchers here sought to analyze headache phenomenology in a large group of patients with mitochondrial disorders. In this study, patients with mitochondrial diseases had a higher prevalence of headache than reported in the general population. Tension-type headache (TTH) was more frequent than migraine in all phenotype and genotype groups. Findings, in addition, revealed that the current International Classification of Headache Disorders (ICHD-3 beta) exclusively focused on MELAS syndrome as vasculopathy does not consider the broader spectrum of headache phenotypes in mitochondrial disorders.