Latenstein CSS, et al. - In this systematic review and meta-analysis involving 1227 patients, researchers ascertained the prevalence of dyspepsia in patients with uncomplicated cholecystolithiasis [defined as gallstones in the gallbladder, in the absence of stones in bile ducts, cholecystitis, or cholangitis]. For articles reporting the prevalence of dyspepsia in adults (≥18 years) with uncomplicated cholecystolithiasis, the electronic databases Medline, Embase, and Web of Science were searched. Data reported that the pooled prevalence of dyspepsia in cholecystolithiasis patients was 65.7%, however, heterogeneity was large across studies. According to the findings, most patients with cholecystolithiasis have functional dyspepsia-like symptoms. This phenomenon should be known to doctors who meet patients with gallstones and non-specific abdominal symptoms. Measures are needed to select patients to take advantage of cholecystectomy to avoid inappropriate surgery.