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Prevalence of delusions in drug-naïve Alzheimer's disease patients: A meta-analysis

International Journal of Geriatric Psychiatry Oct 14, 2017

Lai L, et al. - The clinicians conducted this meta-analysis to ascertain the prevalence of delusions in drug-naïve (no cholinesterase inhibitor or neuroleptic medications) Alzheimer's disease (AD) patients. In AD patients, they calculated a 29.1% prevalence rate of delusions. They found a trend towards increasing delusion prevalence in concordance with increasing severity of dementia. The obtained prevalence had to motivate clinicians to screen carefully for delusions as the delusions were associated with poorer outcomes. Future studies were required due to current literature limitations, with sub-analyses on dementia severity, and other neurobiological factors influencing the presence of delusions.
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