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Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: A systematic review and meta-analysis

The Lancet: Gastroenterology & Hepatology Mar 26, 2019

Li J, et al. - In this systematic review and meta-analysis, researchers evaluated non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disease worldwide, prevalence, incidence, and outcomes in the Asian population. From the beginning to January 17, 2019, PubMed, EMBASE, and the Cochrane Library were searched for studies reporting NAFLD prevalence, incidence, or outcome in Asia. Of the 4,995 records identified for analysis, 237 studies (13,044,518 participants) were used for this study. Data reported that the overall prevalence of NAFLD was 29.62% irrespective of the method used for diagnosis. Investigators found increasing prevalence of NAFLD in Asia, which was related to outcomes such as hepatocellular carcinoma and death. In Asia, there is a need for public health strategies that focus on the drivers of this increasing epidemic and its related complications, particularly in older obese men and other high-risk groups.

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